Liver Disease
In addition to the vitamin K-dependent coagulation factors, the liver synthesizes Factor V, fibrinogen, plasminogen, and Factors XII and XL Patients with advanced liver disease commonly suffer bleeding tendencies. If these mainly involve deficiencies of vitamin K-dependent clotting factors, they are corrected by administering parenteral vitamin K. Bleeding in severe liver disease also results from dysfibrinogenemias, localized DIC, lack of Factor V, increased fibrinolysis, and thrombocytopenia. Treatment of these deficiencies employs fresh frozen plasma.
Tags: coag, deficiencies, fresh frozen plasma, plasminogen, tendencies, thrombocytopenia, thrombocytopenia treatment, ting, vitamin k, xl
- Disseminated Intravascular Coagulation
- ACQUIRED DISORDERS OF BLOOD COAGULATION
- Acquired Vitamin K Deficiency
- Liver Disease
- ACQUIRED DISORDERS OF PLATELET FUNCTIOII
- QUALITATIVE PLATELET DISORDERS
- INHERITED DISORDERS OF BLOOD COAGULATION
- SCREENING FOR DISORDERS OF BLOOD COAGULATION
- INHERITED DISORDERS OF OTHER COAGULATION FACTORS
- Renal Disease