Disseminated Intravascular Coagulation
DIC represents the consumption of coagulation factors resulting from intravascular activation of the coagulation process with secondary activation of fibrinolysis. Depending upon the rates of these two processes, the compensatory synthesis of pro-coagulants, and the nature of the underlying disease, DIC may cause either thrombosis or hemorrhage. DIC is always secondary to another disease process and often resolves when the primary disease is controlled. Intravascular coagulation is initiated by release of procoagulant substances into the blood (amniotic fluid embolism, snakebite, abruptio placenta, malignancy, crush injury), by contact of blood with an abnormal surface (infections, burns, extracorporeal circulation, grafts), or by generation of procoagulants in the blood (promyelocytic leukemia, hemolytic trans;, fusion reactions). The formation of mierothrombyj within the circulation secondarily activates fibri-jj nolysis, as does the presence of injured endothej? Hum. Circulating plasmm may’further deplete’ Factors V and VIII and cleave fibrinogen. The deg* radation products of both’fibrinogen and fibrin’ (formed by thrombin or plasmin action) act as cir’^’ culating anticoagulants, delay fibrin polymeriza^ tion, and impair platelet function.
Tags: anticoagulants, cir, circulation, coagulants, coagulation factors, consumption, crush injury, dic, dis ease, embolism, fibrinogen, fibrinolysis, fusion reactions, grafts, leukemia, malignancy, presence, synthesis, thrombin, thrombosis
- Renal Disease
- INHERITED DISORDERS OF BLOOD COAGULATION
- ACQUIRED DISORDERS OF BLOOD COAGULATION
- Acquired Vitamin K Deficiency
- Liver Disease
- SCREENING FOR DISORDERS OF BLOOD COAGULATION
- INHERITED DISORDERS OF OTHER COAGULATION FACTORS
- ACQUIRED DISORDERS OF PLATELET FUNCTIOII
- QUALITATIVE PLATELET DISORDERS
- Disseminated Intravascular Coagulation